{"product_id":"pea-palmitoylethanolamide","title":"PEA Palmitoylethanolamide","description":"\u003cmeta charset=\"utf-8\"\u003e\n\u003cdiv class=\"medicinal_ingredients\"\u003e\n\u003cdiv class=\"uses_benefits\"\u003e\n\u003ch3\u003eBenefits\u003c\/h3\u003e\n\u003cul class=\"feature-list\"\u003e\n\u003cli\u003eFor chronic pain relief\u003c\/li\u003e\n\u003cli\u003eOffers a natural source of PEA from non-GMO saffl ower oil\u003c\/li\u003e\n\u003cli\u003eMicronized for improved bioavailability\u003c\/li\u003e\n\u003cli\u003eProvides 400 mg PEA in each capsule, allowing for easyand clinically relevant dosing\u003c\/li\u003e\n\u003cli\u003eSuitable for vegetarians and vegans\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"feature_summary\"\u003e\n\u003ch3\u003eFeature Summary\u003c\/h3\u003e\n\u003cp\u003ePalmitoylethanolamide (PEA) is an endogenously produced lipid that mediates the resolution of neuroinflammation and clinically reduces pain from a variety of sources.\u003csup\u003e1,2,3\u003cspan\u003e \u003c\/span\u003e\u003c\/sup\u003ePEA is a type of fatty acid ethanolamine produced in microglia and mast cells, where it downregulates the activation of both cell types; levels of PEA are increased in brain areas involved in nociception, and appear to modulate protective responses to both inflammation and pain.\u003csup\u003e4\u003c\/sup\u003e\u003cspan\u003e \u003c\/span\u003eIts effects are mediated via direct activation of PPAR-a and GPR55 receptors, and potentially by indirect activation of CB1 and CB2 receptors and the TRPV1 channel (i.e., the capsaicin receptor).\u003csup\u003e5,6\u003c\/sup\u003e\u003c\/p\u003e\n\u003cp\u003eIn clinical trials, PEA has been shown to reduce pain levels from a variety of chronic conditions (of at least 6 months duration) where pain was not controlled by standard therapies, demonstrating effectiveness both alone and when combined with standard treatments.\u003csup\u003e7\u003c\/sup\u003e\u003cspan\u003e \u003c\/span\u003ePEA has been shown to be efficacious for pain resulting from nerve compression syndromes, including sciatica and carpal tunnel syndrome.\u003csup\u003e8\u003c\/sup\u003e\u003cspan\u003e \u003c\/span\u003eRandomized trials have also shown benefit for pain control for specific conditions, including TMJ,\u003csup\u003e9\u003c\/sup\u003e\u003cspan\u003e \u003c\/span\u003eas well as for depressive symptoms in major depressive disorder when used in conjunction with antidepressants.\u003csup\u003e10\u003c\/sup\u003e\u003cspan\u003e \u003c\/span\u003eIn addition, PEA has been shown to improve endothelial function and reduce intraocular pressure among patients with ocular hypertension.\u003csup\u003e11,12\u003c\/sup\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003ch3\u003e\u003cbr\u003e\u003c\/h3\u003e\n\u003ch3\u003eMedicinal Ingredients\u003c\/h3\u003e\n\u003ctable border=\"1\" class=\"fg-table\" collapse=\"collapse\"\u003e\n\u003cthead class=\"fg-head\"\u003e\n\u003ctr\u003e\n\u003ctd colspan=\"2\"\u003e\u003cb\u003eEach Capsule Contains:\u003c\/b\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd colspan=\"1\"\u003ePalmitoylethanolamide (PEA)\u003c\/td\u003e\n\u003ctd\u003e400 mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd colspan=\"2\"\u003ePEA (palmitoylethanolamide) is a fatty-acid-like compound which is extracted from non-GMO safflower oil. Micronized for improved solubility and absorption.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"non_medicinal_ingredients\"\u003e\n\u003ch3\u003eNon-Medicinal Ingredients\u003c\/h3\u003e\n\u003cp\u003eVegetarian capsule (carbohydrate gum [cellulose], purified water), microcrystalline cellulose, vegetable grade magnesium stearate (lubricant), silica, stearic acid.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"dosage site-2\"\u003e\n\u003ch3\u003eDosage:\u003c\/h3\u003e\n\u003cp\u003e\u003cb\u003eRecommended Adult Dose:\u003cspan\u003e \u003c\/span\u003e\u003c\/b\u003e1 capsule 1–3 times per day or as directed by a health care practitioner.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"allergens\"\u003e\n\u003ch3\u003eAllergens:\u003c\/h3\u003e\n\u003cp\u003eContains no artificial colours, preservatives, or sweeteners; no dairy, starch, sugar, wheat, gluten, yeast, soy, corn, egg, fish, shellfish, animal products, salt, tree nuts, or GMOs. Suitable for vegetarians\/vegans. Sealed for your protection. Do not use if seal is broken. For freshness, store in a cool, dry place.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Assured Natural","offers":[{"title":"Default Title","offer_id":43648514031784,"sku":"BIOPEA001","price":44.99,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0515\/6614\/9800\/files\/ScreenShot2023-05-16at1.46.46PM.png?v=1684259322","url":"https:\/\/institute-for-hormonal-health.myshopify.com\/products\/pea-palmitoylethanolamide","provider":"Gracemed Functional Medicine and Hormonal Health","version":"1.0","type":"link"}